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99.3 % Veterinary medicine Niclosamide,Niclosamide raw powder with BP standard
Niclosamide is an antihelmintic that is active against most tapeworms.
Niclosamide is an orally bioavailable chlorinated salicylanilide, with anthelmintic and potential antineoplastic activity. Upon oral administration, niclosamide specifically induces degradation of the androgen receptor (AR) variant V7 (AR-V7) through the proteasome-mediated pathway. This downregulates the expression of the AR variant, inhibits AR-V7-mediated transcriptional activity, and reduces AR-V7 recruitment to the prostate-specific antigen (PSA) gene promoter. Niclosamide also prevents AR-V7-mediated STAT3 phosphorylation and activation. This inhibits AR/STAT3-mediated signaling and prevents expression of STAT3 target genes. Altogether, this may inhibit growth of AR-V7-overexpressing cancer cells. The AR-V7 variant, which is encoded by contiguous splicing of AR exons 1/2/3/CE3, is upregulated in a variety of cancer cell types, and is associated with both cancer progression and resistance to AR-targeted
Niclosamide is used for the treatment of most tapeworm infections. Helminths (worms) are multicellular organisms that infect very large numbers of humans and cause a broad range of diseases. Over 1 billion people are infected with intestinal nematodes, and many millions are infected with filarial nematodes, flukes, and tapeworms. They are an even greater problem in domestic animals.
The COA of Niclosamide :
|CAS No.||50-65-7||Outer Packing||25KG|
|Production date||2017.09.06||Shelf life||2018.09.05|
|Standard adopted||All Items Comply with BP2000|
|Items of analysis||Specification||Results|
|Description||Yellowish White Powder||Yellowish White Powder|
|Identification||Test B E C Complies||Complies|
|Loss on Drying||≤0.5%||0.40%|