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99.3 % Veterinary medicine Niclosamide , Niclosamide raw powder with BP standard

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99.3 % Veterinary medicine Niclosamide , Niclosamide raw powder with BP standard

China 99.3 % Veterinary medicine Niclosamide , Niclosamide raw powder with BP standard supplier
99.3 % Veterinary medicine Niclosamide , Niclosamide raw powder with BP standard supplier 99.3 % Veterinary medicine Niclosamide , Niclosamide raw powder with BP standard supplier

Large Image :  99.3 % Veterinary medicine Niclosamide , Niclosamide raw powder with BP standard

Product Details:

Place of Origin: Wuhan,Hubei
Brand Name: Yuancheng
Certification: ISO9001
Model Number: 50-65-7

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Price: negotiate
Packaging Details: well packed
Delivery Time: 4-7 working days
Payment Terms: T/T, Western Union, MoneyGram,bitocin
Supply Ability: 5000kg/M
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Detailed Product Description
Name: Niclosamide MF: C13H8Cl2N2O4
MW: 327.12 CAS: 50-65-7
Purity: 99.3% Appearance: Yellow Powder

99.3 % Veterinary medicine Niclosamide,Niclosamide raw powder with BP standard

Niclosamide
MF:C13H8Cl2N2O4
MW:327.12
CAS:50-65-7
Appearance:yellow powder
Purity:99.3%
Standard:BP standard

Niclosamide is an antihelmintic that is active against most tapeworms.

Niclosamide is an orally bioavailable chlorinated salicylanilide, with anthelmintic and potential antineoplastic activity. Upon oral administration, niclosamide specifically induces degradation of the androgen receptor (AR) variant V7 (AR-V7) through the proteasome-mediated pathway. This downregulates the expression of the AR variant, inhibits AR-V7-mediated transcriptional activity, and reduces AR-V7 recruitment to the prostate-specific antigen (PSA) gene promoter. Niclosamide also prevents AR-V7-mediated STAT3 phosphorylation and activation. This inhibits AR/STAT3-mediated signaling and prevents expression of STAT3 target genes. Altogether, this may inhibit growth of AR-V7-overexpressing cancer cells. The AR-V7 variant, which is encoded by contiguous splicing of AR exons 1/2/3/CE3, is upregulated in a variety of cancer cell types, and is associated with both cancer progression and resistance to AR-targeted

Niclosamide is used for the treatment of most tapeworm infections. Helminths (worms) are multicellular organisms that infect very large numbers of humans and cause a broad range of diseases. Over 1 billion people are infected with intestinal nematodes, and many millions are infected with filarial nematodes, flukes, and tapeworms. They are an even greater problem in domestic animals.

 

The COA of Niclosamide :

 

Product name Niclosamide
CAS No. 50-65-7 Outer Packing 25KG
Production date 2017.09.06 Shelf life 2018.09.05
Standard adopted All Items Comply with BP2000
Items of analysis Specification Results
Description Yellowish White Powder Yellowish White Powder
Identification Test B E C Complies Complies
5-Chlorosalicylic acid ≤60ppm <50ppm
2-Chloro-4-nitroaniline;o-chloro-nitroaniline ≤100ppm <85ppm
Melting point 228-232℃ 229-230.℃
Related Substances ≤0.2 0.14
CL ≤500ppm <400pm
Loss on Drying ≤0.5% 0.40%
sulfated ash ≤0.1% 0.07%
Assay 98.0-101% 99.30%
Conclusion Qualified

 

 

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