Hangzhou Fuluo Biological Technology Co.,Ltd.
High quality, competitive price, fast delivery
Payment & Shipping Terms:
|Purity:||99.51%||Appearance:||White Crystalline Powder|
99.51% raw salbutamol white powder,salbutamol with BP Standard
Appearance:white crystalline powder
Salbutamol is a short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.
Albuterol is a racemic mixture of the r-isomer levalbuterol and s-albuterol, a short-acting sympathomimetic agent with bronchodilator activity. Albuterol stimulates beta-2 adrenergic receptors in the lungs, thereby activating the enzyme adenylate cyclase that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP). Increased cAMP concentrations relax bronchial smooth muscle, relieve bronchospasms, and reduce inflammatory cell mediator release, especially from mast cells. Albuterol although to a lesser extent, also stimulates beta-1 adrenergic receptors, thereby increasing the force and rate of myocardial contraction.
The beta-2 adrenergic agonists are a large group of drugs that mimic the actions of naturally occurring catecholamines such as norepinephrine, epinephrine and dopamine. Direct agonists directly interact with the adrenergic receptors, whereas indirect agonists typically stimulate the release of endogenous catecholamines. The beta-2 adrenergic agonists act mainly on the smooth muscle of the vasculature, bronchial tree, intestines and uterus. These agents also act on the liver stimulating glycogenolysis and release of glucose from the liver and muscle (particularly if used in high doses). The beta-2 adrenergic agonists are used largely as bronchodilators in the management of asthma, both in control of acute symptomatic attacks as well as chronic, long term prevention and management. These agents are some of the most commonly prescribed drugs for asthma and are widely used and proven to be well tolerated and safe. The use of beta adrenergic agonists in asthma has not been associated with elevations in serum aminotransferase or alkaline phosphatase levels or in causing clinically apparent liver disease. When given in large doses or after intentional overdose, beta adrenergic agonists can cause liver injury. Most case reports of liver damage from these agents have been associated with their use in control of premature labor (for their effects on relaxation of uterine smooth muscle). The liver injury typically arises within a few days of starting high dose intravenous beta adrenergic agonists, is usually asymptomatic, not associated with jaundice, and rapidly reversed once the medication is stopped.
The COA of salbutamol:
|Product name||Salbutamol/Salbutamol Base|
|CAS No.||18559-94-9||Outer Packing||25KG|
|Production date||Jan 16th., 2017||Shelf life||Jan, 2010|
|Items of analysis||Specification||Results|
|Characteristics||White or almost white crystalline powder||Complies|
|Identification||A. UV specific absorption / A 1% 1CM: 66-75 B. by TLC ; C. by IR; D. by Color Reaction||A. 67.12 B.C.D.Complies|
|Solubility||Freely soluble in ethanol (96%), sparingly soluble in water, slightly soluble in ether||Complies|
|Melting Range||152.0 –159.0℃||157.0℃|
|Clarity and colour of solution||2% solution in methanol is clear and not more intensely colored that reference solution BY5||Complies|
|Optical Rotation||-0.10° ~ +0.10°||+0.0°|
|Single impurity D,F,G||NMT: 0.30%;||Not detected;|
|Single impurity A,B,C,E,H,I||NMT: 0.30%||Not detected;|
|Imputiry J (Absorbance at 310)||0.1% w/w max.||0.08%|
|Residual Solvent||Methanol: NMT3000PPM||Complies|
|Loss on drying||≤0.5% (W/W)||0.20%|
|Sulfated Ash||≤0.10% (W/W)||0.03%|
|Assay (On dried basis)||98.00% --101.00% (W/W)||99.51%|