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99.51% Raw Salbutamol Pharmaceutical Raw Materials White Powder , Salbutamol With BP Standard

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99.51% Raw Salbutamol Pharmaceutical Raw Materials White Powder , Salbutamol With BP Standard

China 99.51% Raw Salbutamol Pharmaceutical Raw Materials White Powder , Salbutamol With BP Standard supplier
99.51% Raw Salbutamol Pharmaceutical Raw Materials White Powder , Salbutamol With BP Standard supplier 99.51% Raw Salbutamol Pharmaceutical Raw Materials White Powder , Salbutamol With BP Standard supplier

Large Image :  99.51% Raw Salbutamol Pharmaceutical Raw Materials White Powder , Salbutamol With BP Standard

Product Details:

Place of Origin: Wuhan,Hubei
Brand Name: Yuancheng
Certification: ISO9001
Model Number: 18559-94-9

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Price: negotiate
Packaging Details: well packed
Delivery Time: 4-7 working days
Payment Terms: T/T, Western Union, MoneyGram,bitocin
Supply Ability: 5000kg/M
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Detailed Product Description
Name: 18559-94-9 MF: C13H21NO3
MW: 239.31 CAS: 18559-94-9
Purity: 99.51% Appearance: White Crystalline Powder

99.51% raw salbutamol white powder,salbutamol with BP Standard

salbutamol
MF:C13H21NO3
MW:239.31
CAS:18559-94-9
Appearance:white crystalline powder
Purity:99.51%

 

Salbutamol is a short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.

 

Albuterol is a racemic mixture of the r-isomer levalbuterol and s-albuterol, a short-acting sympathomimetic agent with bronchodilator activity. Albuterol stimulates beta-2 adrenergic receptors in the lungs, thereby activating the enzyme adenylate cyclase that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP). Increased cAMP concentrations relax bronchial smooth muscle, relieve bronchospasms, and reduce inflammatory cell mediator release, especially from mast cells. Albuterol although to a lesser extent, also stimulates beta-1 adrenergic receptors, thereby increasing the force and rate of myocardial contraction.

 

The beta-2 adrenergic agonists are a large group of drugs that mimic the actions of naturally occurring catecholamines such as norepinephrine, epinephrine and dopamine. Direct agonists directly interact with the adrenergic receptors, whereas indirect agonists typically stimulate the release of endogenous catecholamines. The beta-2 adrenergic agonists act mainly on the smooth muscle of the vasculature, bronchial tree, intestines and uterus. These agents also act on the liver stimulating glycogenolysis and release of glucose from the liver and muscle (particularly if used in high doses). The beta-2 adrenergic agonists are used largely as bronchodilators in the management of asthma, both in control of acute symptomatic attacks as well as chronic, long term prevention and management. These agents are some of the most commonly prescribed drugs for asthma and are widely used and proven to be well tolerated and safe. The use of beta adrenergic agonists in asthma has not been associated with elevations in serum aminotransferase or alkaline phosphatase levels or in causing clinically apparent liver disease. When given in large doses or after intentional overdose, beta adrenergic agonists can cause liver injury. Most case reports of liver damage from these agents have been associated with their use in control of premature labor (for their effects on relaxation of uterine smooth muscle). The liver injury typically arises within a few days of starting high dose intravenous beta adrenergic agonists, is usually asymptomatic, not associated with jaundice, and rapidly reversed once the medication is stopped.

 

The COA of salbutamol:

Product name Salbutamol/Salbutamol Base
CAS No. 18559-94-9 Outer Packing 25KG
Production date Jan 16th., 2017 Shelf life Jan, 2010
Standard adopted BP2013
Items of analysis Specification Results
Characteristics White or almost white crystalline powder Complies
Identification A. UV specific absorption / A 1% 1CM: 66-75 B. by TLC ; C. by IR; D. by Color Reaction A. 67.12 B.C.D.Complies
Solubility Freely soluble in ethanol (96%), sparingly soluble in water, slightly soluble in ether Complies
Melting Range 152.0 –159.0℃ 157.0℃
Clarity and colour of solution 2% solution in methanol is clear and not more intensely colored that reference solution BY5 Complies
Optical Rotation -0.10° ~ +0.10° +0.0°
Single impurity D,F,G NMT: 0.30%; Not detected;
Single impurity A,B,C,E,H,I NMT: 0.30% Not detected;
Unspecified impurity NMT0.1% 0.05%
Total impurities NMT1.0% 0.05%
Imputiry J (Absorbance at 310) 0.1% w/w max. 0.08%
Boron ≤ 50PPM 38.50PPM
Residual Solvent Methanol: NMT3000PPM Complies
Loss on drying ≤0.5% (W/W) 0.20%
Sulfated Ash ≤0.10% (W/W) 0.03%
Assay (On dried basis) 98.00% --101.00% (W/W) 99.51%
Conclusion Qualified

 

 

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