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99.6% Chlorphenamine maleate Pharmaceutical Raw Materials Raw Powder

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99.6% Chlorphenamine maleate Pharmaceutical Raw Materials Raw Powder

China 99.6% Chlorphenamine maleate Pharmaceutical Raw Materials Raw Powder supplier
99.6% Chlorphenamine maleate Pharmaceutical Raw Materials Raw Powder supplier 99.6% Chlorphenamine maleate Pharmaceutical Raw Materials Raw Powder supplier

Large Image :  99.6% Chlorphenamine maleate Pharmaceutical Raw Materials Raw Powder

Product Details:

Place of Origin: Wuhan,Hubei
Brand Name: Yuancheng
Certification: ISO9001
Model Number: 113-92-8

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Price: negotiate
Packaging Details: well packed
Delivery Time: 4-7 working days
Payment Terms: T/T, Western Union, MoneyGram,bitocin
Supply Ability: 5000kg/M
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Detailed Product Description
Name: Chlorpheniramine Maleate MF: C20H23ClN2O4
MW: 390.86 CAS: 113-92-8
Purity: 99.6% Appearance: White Crystalline Powder

99.6% Chlorphenamine maleate Raw Powder with BP Standard

Chlorpheniramine maleate
Molecular Formula:C20H23ClN2O4
Formula Weight:390.86
CAS No.:113-92-8
Appearance:white crystalline powder
Purity:99.6%
Standard:BP standard

 

Chlorphenamine maleate is a medicine known as an antihistamine. When the body comes into contact with something it is allergic to, such as pollen, animal hair or fur, house dust or insect bites, it produces a chemical called histamine. This causes itchy, watery eyes, running or blocked nose, sneezing and rashes, which may itch. Chlorphenamine maleate blocks the effects of histamine and so reduces these symptoms.

 

Chlorpheniramine is an antihistamine used to relieve symptoms of allergy, hay fever, and the common cold. These symptoms include rash, watery eyes, itchy eyes/nose/throat/skin, cough, runny nose, and sneezing.

 

Chlorpheniramine inhibits the [3H]mepyramine binding to the histamine H1 receptor in guinea pig cortex with IC50 of 8.8 nM. Chlorpheniramine inhibits the proliferation of MCF-7, MDA-MB 231, and Ehrlich cells in a dose-response manner, and significantly reduces the ornithine decarboxylase mRNA translation by 50%-70% at the 250 μM. Chlorpheniramine displaces of [3H]pyrilamine from human histamine receptor subtype 1 expressed in CHO cells with IC50 of 66 nM. Chlorpheniramine displays antimalarial activity against CQS strain (D6) and MDR strain (Dd2) of P. falciparum with IC50 of 61.2 uM and 3.9 uM, respectively. Chlorpheniramine displays cytotoxicity against the proliferation of concanavalin A-induced murine splenic lymphocytes with IC50 of 33.4 μM. Chlorpheniramine treatment in human salivary gland cells more significantly inhibits the histamine-induced [Ca2+]i increase in a concentration-dependent manner with IC50 of 128 nM than that of carbachol-induced [Ca2+]i increase with an IC50 of 43.9 μM.

 

The COA of Chlorpheniramine maleate:

Product name Chlorphenamine Maleate
CAS No. 113-92-8 Outer Packing 25kg/drum
Production date Feb,2017 Shelf life Jan,2022
Standard adopted BP2014
Items of analysis Specification Results
Appearance white or almost white,crystalline powder complies
Solubility Freely soluble in water,soluble in ethanol(96%) complies
identification A. melting point:130-135℃ 131-132℃
B. Infrared absorption spectrophotometry. complies
C. optical rotation:(see tests) complies
solutions dissolve 2.0g in water and dilute to 20ml with the same solvent complies
appearance of solution solution S is clear and not more intensely colored than reference solution BY6 complies
related substances liquid chromatography complies
1.Impurity A NMT 0.2% complies
2.Impurity B NMT 0.1% complies
3.Impurity C NMT 0.1% complies
4.Impurity D NMT 0.1% complies
5.Unspecified impurities NMT 0.1% complies
6.Total NMT 0.5% complies
heavy metals max.20ppm complies
loss on drying max.0.5%,determined on 1.000g by drying in an oven at 105℃ for 4h. 0.22%
sulphated ash max.0.1%,determined on 1.0g 0.07%
assay 98-101%(dried substance) 99.60%
Conclusion Qualified

 

99.6% Chlorphenamine maleate Pharmaceutical Raw Materials Raw Powder

 

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