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|Name:||AICAR||Appearance:||Light Yellow Powder|
98% Human Growth Peptide AICAR With Fast Delivery
AICAR is a cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK).
AMPK is a heterodimeric protein serine/threonine kinase that regulates the energy status of cells to protect cell from metabolic stress. AMPK phosphorylates various metabolic enzymes to activate catabolic pathways (e.g. ketogenesis) and block anabolic pathways (e.g. protein synthesis).
In rat primary astrocytes, microglia, and peritoneal macrophages, AICAR does-dependently inhibits the LPS-induced production of TNFα, IL-1β, and IL-6. AICAR treatment also blocks LPS-induced nitrite production and iNOS gene expression in those cells in a dose-dependent manner by activation of AMPK. Moreover, AICAR inhibits the LPS-induced C/EBP nuclear relocation via downregulating the expression of C/EBP-δ.
In LPS-injected rats, AICAR treatment abolishes LPS-mediated increased levels of IL-1β and IFN-γ in serum. AICAR treatment also strongly inhibits the LPS-induced expression of iNOS in peritoneal macrophages isolated from these rats. Furthermore, the intraperitoneal injection of LPS significantly induces the expression of TNFα, IL-1β, and IFN-γ message in the rat spleen.
AICAR as part of stacks and combined with changes in training and/or diet.
AICAR, at sufficient and quite substantial concentration, is effective at activating AMPK and inducing a cellular state as if exercise had been performed, or energy stores were low and fat therefore needed to be burned.
A number of examples will follow showing AICAR doses uses in research studies, results from treatment, and approximate human equivalent doses, assuming an about-200 lb (90 kg) human for illustration:
Here is where AICAR becomes a pipe dream for anyone who is not a top level endurance athlete or bodybuilder. The dosages recommended to achieve the benefits from this peptide are insanely high. AICAR must be dosed at around 500mgs per kilogram (kg) of body weight.
In general I would recommend against using AICAR, but if wishing to do so anyway, I would use 500 mg/day for a limited period of time such as 4 weeks. For almost all persons this would be financially impractical with 50 mg pre-prepared vials.
AICAR and GW501516 (cardarine) used together they make a potent endurance stack. One of the differences between the two is that GW is a PPAR-delta agonist, while AICAR is a PPAR-delta AMPK axis agonist.
In terms of doping, GW501516 is easily detectable for up to 40 days in urine tests, as it is not a naturally occuring substance in the body. Meanwhile, AICAR is a naturally occuring substance in the body, so this makes it more difficult to test for. To combat this, a baseline value was established, which determines if someone is using AICAR to dope with. Nevertheless, it has still been proven to be harder to catch cheaters using AICAR than GW501516
Dosages range from 150 milligrams (mg) per day (if stacked with GW), up to 500mg a day when used solo. Considering the fact that each bottle typically comes in 50mg dosages, that is quite expensive, as already mentioned above. Economically, it makes most sense to run AICAR during the 4 weeks leading up to your competition..
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|Boldenone Undecylenate (Equipoise)||13103-34-9|
|Superdrol Powder (Methyl-drostanolone)||3381-88-2|
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