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Tetracaine Hydrochloride Local Anesthetic Agents Tetracaine HCl CAS 136-47-0 Pain Killer

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Tetracaine Hydrochloride Local Anesthetic Agents Tetracaine HCl CAS 136-47-0 Pain Killer

China Tetracaine Hydrochloride Local Anesthetic Agents Tetracaine HCl CAS 136-47-0 Pain Killer supplier
Tetracaine Hydrochloride Local Anesthetic Agents Tetracaine HCl CAS 136-47-0 Pain Killer supplier Tetracaine Hydrochloride Local Anesthetic Agents Tetracaine HCl CAS 136-47-0 Pain Killer supplier

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Product Details:

Place of Origin: Wuhan,Hubei
Brand Name: Saichuang
Certification: ISO9001
Model Number: 136-47-0

Payment & Shipping Terms:

Minimum Order Quantity: 10 gram
Price: Negotiable
Packaging Details: Discreet package for delivery guarantee
Delivery Time: 3-7 working days
Payment Terms: T/T, Western Union, MoneyGram,Bitcoin
Supply Ability: 1ton/month
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Detailed Product Description
Product Name: Tetracaine Hydrochloride,Tetracaine HCl Alias: Amethocaine
CAS NO: 136-47-0 EINECS: 205-248-5
MF: C15H25ClN2O2 MW: 300.82
Melting Point: 149°C Assay: 99%
Grade: Pharmaceutical Grade Email: Jay@ycgmp.com

Descriptin

 

Tetracaine HCl is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.

Tetracaine is the T in Tac, a mixture of 5 to 12 per cent tetracaine, 5‱ (per myriad), a half per mille (0.5‰), or .05 per cent (1 part in 2000) adrenaline, and 4 or 10 per cent cocaine hydrochloride used in ear, nose & throat surgery and in the emergemcy department where numbing of the surface is needed rapidly, especially when children have been injured in the eye, ear, or other sensitive locations.

It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.

A systematic review and meta-analysis of randomised controlled trials investigated tetracaine for use in emergency departments, especially for IV cannulation in children, in view of its analgesic and cost-saving properties - however it did not find a statistically significant improvement in first attempt cannulations.

 

Application

 

Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.


In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.

 

Usage


The efficacy profile of lidocaine as a local anesthetic is characterized by a rapid onset of action and intermediate duration of efficacy. Therefore, lidocaine is suitable for infiltration, block, and surface anesthesia. Longer-acting substances such as bupivacaine are sometimes given preference for subdural and epidural anesthesias; lidocaine,though, has the advantage of a rapid onset of action.


In dental anesthesia, a relative insensitivity to lidocaine can occur for anatomical reasons due to unexpected positions of nerves. Some people with Ehlers-Danlos syndrome are insensitive to lidocaine.

 

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Tetracaine Hydrochloride Local Anesthetic Agents Tetracaine HCl CAS 136-47-0 Pain Killer

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