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99.5% Anti - Inflammatory Local Anesthetic Powder Procaine Hydrochloride CAS 51-05-8

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99.5% Anti - Inflammatory Local Anesthetic Powder Procaine Hydrochloride CAS 51-05-8

China 99.5% Anti - Inflammatory Local Anesthetic Powder Procaine Hydrochloride CAS 51-05-8 supplier
99.5% Anti - Inflammatory Local Anesthetic Powder Procaine Hydrochloride CAS 51-05-8 supplier 99.5% Anti - Inflammatory Local Anesthetic Powder Procaine Hydrochloride CAS 51-05-8 supplier

Large Image :  99.5% Anti - Inflammatory Local Anesthetic Powder Procaine Hydrochloride CAS 51-05-8

Product Details:

Place of Origin: Wuhan,Hubei
Brand Name: Saichuang
Certification: ISO9001
Model Number: 51-05-8

Payment & Shipping Terms:

Minimum Order Quantity: 10 gram
Price: Negotiable
Packaging Details: Discreet package for delivery guarantee
Delivery Time: 3-7 working days
Payment Terms: T/T, Western Union, MoneyGram,Bitcoin
Supply Ability: 1ton/month
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Detailed Product Description
Product Name: Procaine HCl Alias: Procaine Hydrochloride;Aminocaine;Anadolor;Atoxicocaine;Neocaine,Procaine Hydrochlo,Procaine
CAS Register Number: 51-05-8 Molecular Formula: C13H21ClN2O2
Molecular Weight: 272.77 Melting Point: 155-156 °C
Assay: 99% EINECS: 200-077-2
Grade: Pharmaceutical Grade Storage: Shading, Confined Preservation
Appearance: White Crystalline Powder Email: Jay@ycgmp.com

Description


Procaine hydrochloride is a local anesthetic that can temporarily block the conduction of nerve fibers and has a narcotic effect, the role of strong, low toxicity, and no addiction, but the skin, mucous membranes

penetrate weak, suitable for surface anesthesia, patients are used for infiltration, spine and conduction anesthesia.


Application


Procaine HCl is a local anesthetic drug of the amino ester group. It is used primarily to reduce the pain of intramuscular injection of penicillin, and it is also used in dentistry. Owing to the ubiquity of the trade name Novocain, in some regions procaine is referred to generically as novocaine. It acts mainly by being a sodium channel blocker.Today it is used therapeutically in some countries due to its sympatholytic,anti-inflammatory, perfusion enhancing, and mood enhancing effects.


Procaine HCl is indicated for the production of local or regional analgesia and anesthesia by local infiltration and peripheral nerve block techniques.


Application of procaine leads to the depression of neuronal activity. The depression causes the nervous system to become hypersensitive producing restlessness and shaking, leading to minor to severe convulsions. Studies on animals have shown the use of procaine led to the increase of dopamine and serotonin levels in the brain.Other issues may occur because of varying individual tolerance to procaine dosage. Nervousness and dizziness can arise from the excitation of the central nervous system, which may lead to respiratory failure if overdosed. Procaine may also induce weakening of the myocardium leading to cardiac arrest.


Procaine can also cause allergic reactions causing the individuals to have problems with breathing, rashes, and swelling. Allergic reactions to procaine are usually not in response to procaine itself, but to its metabolite PABA. About one in 3000 people have an atypical form of pseudocholinesterase, which does not hydrolyze ester anesthetics such as procaine, resulting in a prolonged period of high levels of the anesthetic in the blood and increased toxicity.

 

Usage

 

procaine hydrochloride was first synthesized by German chemist Albert Einhorn in 1905. He is looking for a compound that can be used as an anesthetic, non-toxic, no side effects, no addiction. Dr. Eindhoven is looking for a compound that can replace cocaine as an anesthetic. Cocaine was used as an anesthetic. However, because cocaine is toxic, addictive, destructive to the central nervous system, its use is illegal. Dr. Einhorn was able to produce a compound that showed the properties he was looking for. This new compound he named as procaine.

 

"Pro" means replacement, "cocaine" comes from the word cocaine. Because the names are similar, because they are all anesthetized, there is a lot of confusion about the nature of procaine. Sporaine acts as an anesthetic when injected into the muscle, but when taken as a compound in combination, procaine acts as a vitamin. The procaine HCl solution used as an anesthetic was named Norcaine.

 

Chemical procaine is the PABA ester of amino alcohol DEAE. PABA (p-aminobenzoic acid) is a "B" vitamin. DEAE, (n, n diethylaminoethanol) is a biologically active precursor of & quot; B & quot; vitamin choline. (Figure 1) procaine is usually used in the form of hydrochloride (procaine HCl) because it is highly water soluble. Oral administration of procaine hydrochloride is mainly absorbed through the small intestine villi into the body. Experiments show that most of the procaine HCl enters the blood completely through the molecular formula. In the blood, procaine HCl is rapidly hydrolyzed into the PABA and DEAE by the enzyme, which is the two components of the procaine molecule. These metabolites are removed by the liver, chemically changed, and excreted in the urine.

 

If you are interested in Procaine HCl ,please contact me:

Email:jay@ycgmp.com

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Certificate of Analysis

 

Product name Procaine Hydrochloride
CAS No. 51-05-8 Outer Packing 25KG/drum
Production date 2018.03.03 Shelf life 2021.03.02
Standard adopted USP37
Items of analysis Specification Results
Appearance White Crystalline Powder Conforms
Identification IR Absorption/Reaction of chlorides /Reaction of primary aromatic amines Conforms
Melting point 153-158℃ 156.2-157.6℃
Color and clarity of solution Colorless and clear Conforms
Heavy metals ≤0.002% <0.002%
pH (Acidity) 5.0~6.5 (≤0.02NNaOH0.5ml) 5.5/0.2ml
Chromatographic purity ≤0.05%(Sum≤1.0%) Conforms
Loss on drying ≤0.5% 0.16%
Sulphated ash ≤0.1% 0.05%
Assay 99.0~101.0% 100%
Bacterial endotoxins ≤0.6EU/mg <0.6EU/mg
Conclusion Complies with USP37

 

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99.5% Anti - Inflammatory Local Anesthetic Powder Procaine Hydrochloride CAS 51-05-8

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