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Lidocaine HCL Powder Pharmaceutical Raw Material For Antiarrhythmic CAS 73-78-9

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Lidocaine HCL Powder Pharmaceutical Raw Material For Antiarrhythmic CAS 73-78-9

China Lidocaine HCL Powder Pharmaceutical Raw Material For Antiarrhythmic CAS 73-78-9 supplier
Lidocaine HCL Powder Pharmaceutical Raw Material For Antiarrhythmic CAS 73-78-9 supplier Lidocaine HCL Powder Pharmaceutical Raw Material For Antiarrhythmic CAS 73-78-9 supplier

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Product Details:

Place of Origin: wuhan,hubei
Brand Name: Saichuang
Certification: ISO9001
Model Number: 73-78-9

Payment & Shipping Terms:

Minimum Order Quantity: 10 gram
Price: Negotiable
Packaging Details: Discreet package for delivery guarantee
Delivery Time: 3-5 working days
Payment Terms: T/T, Western Union, MoneyGram,Bitcoin
Supply Ability: 1ton/month
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Detailed Product Description
Product Name: Lidocaine HCl Alias: Lidocaine Hydrochloride
CAS Number: 73-78-9 EINECS: 200-803-8
Appearance: White Crystalline Powder Molecular Formula: C14H23ClN2O
Molecular Weight: 270.8 Melting Point: 80-82°C
Grade: Pharmaceutical Grade Email: Jay@ycgmp.com

Description

 

Lidocaine hydrochloride is a local anesthetic and antiarrhythmic drug. It is clinically used for infiltration anesthesia, epidural anesthesia, surface anesthesia (including in the thoracoscopy or abdominal surgery for mucosal anesthesia) and nerve conduction block. The drug can also be used for acute myocardial infarction after ventricular premature beats and ventricular tachycardia, and for digitalis poisoning, cardiac surgery and ventricular arrhythmias caused by cardiac catheterization. But it is usually ineffective for supraventricular arrhythmias.

 

Lidocaine hydrochloride is an amide local anesthetic. After blood absorption or intravenous administration, the drug has obvious excitement and inhibition of biphasic effects for the central nervous system, and no excitement of the pioneer. With the dose increased, the role or toxicity increased, there is an anti-convulsive effect with sub-poisoning plasma concentration; Blood concentration of more than 5μg • ml-1 can occur convulsions. Lidocaine hydrochloride in low doses can promote outflow of K+ in cardiomyocytes, reduce myocardial autonomy, and has antiarrhythmic effects. In the treatment dose, lidocaine hydrochloride has no significant effect for the electrical activity of cardiomyocytes, atrioventricular conduction and myocardial contraction. Increased plasma concentration may cause slowing of heart conduction, atrioventricular block, inhibition of myocardial contractility and decreased cardiac output.

 

Application

 

Lidocaine hydrochloride is characterized by strong penetration, strong dispersion, rapidly onset. The anesthetic performance is twice that of procaine and the toxicity is1. There is an anesthetic effect after 5 minutes treatments, and anesthesia can last 1 to 1.5 hours, 50% longer than procaine. The drug is effective on the heart of the disease or arrhythmia caused by cardiac glycoside, but on the supraventricular tachycardia is poor. This product is fast and oral ineffective, with short duration, and often used as intravenous administration.

 

Usage and Dosage

The usual dose for adults used in anesthesia
1. A surface anesthesia: 2%~4% solution, not exceed 100mg one time. Injection does not exceed 4.5mg/kg(without epinephrine) and 7mg/kg (with epinephrine of 1: 200000);
2. Caudal block for labor analgesia: 1.0% solution, a limit of 200mg;
3. Epidural block: The thoracolumbar use 1.5% to 2.0% solution, 250~300mg;
4. Anesthesia or intravenous regional anesthesia: 0.25% to 0.5% solution, 50 to 300mg
5. Peripheral nerve block: Brachial plexus (one side) with 1.5% solution, 250 ~ 300mg; Dental use 2% solution, 20 ~ 100mg; Intercostal nerves (each) with 1% solution.

 

If you are interested in Lidocaine hydrochloride,please contact me:

Email:jay@ycgmp.com

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Lidocaine HCL Powder Pharmaceutical Raw Material For Antiarrhythmic CAS 73-78-9

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