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SARMS or selective androgen receptor modulators are well known for administration to the same muscle growth results as the anabolic steroids, but with no side effects opposite to the latter. Japanese scientists are experimenting with a new SARM called YK11, which is said to be one of the most powerful experiments that is more effective than classic steroids such as DHT. YK11 is thought to be SARM, while producing myogenic inhibin.
YK-11 induces muscle cells to make more follistatin which is a strong myostatin inhibitor.Myostatin (also known as growth differentiation factor 8) as a myokine,a protein produced by muscle cells that acts on muscle cells to inhibit myogenesis.Myogenesis is muscle cell growth and differentiation.Research through the years show that when you block myostatin,it allows for significantly more muscle mass.
In addition to that,YK-11 is a bit leaner than LGD-4033,and is excellent for lean gains on par with testosterone.It produces lean,dry,easily kept gains in strength and muscle,and reductions in bodyfat.
YK11 is an effective and specific synthetic REV-ERB. It also has good in vivo plasma / brain exposure. Nuclear receptors REV-ERB-α and REV-ERB-β play an indispensable role in regulating the expression of core clock proteins, promoting rhythms in activity and metabolism. The circadian rhythm behavior of the mouse hypothalamus and the circadian rhythm pattern of the core clock gene expression were altered by the administration of YK11.
Liver, skeletal muscle and adipose tissue in a series of metabolic genes circadian rhythm expression pattern also changed, resulting in increased energy consumption. Treatment of diet-induced obese mice with YK11 reduces fat levels by reducing fat levels, significantly improving dyslipidemia and hyperglycemia. These results suggest that pharmacological targeting of circadian rhythms of synthetic REV-ERB ligands may be beneficial in the treatment of sleep disorders as well as metabolic diseases.
Recommended maximum dose YK11 is require dosages of 2.0-5.0mg b.i.d. in males and 0.5mg-2mg b.i.d. in females to achieve optimal effects in humans for the noted indications.
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Certificate Of Analysis
|Batch NO.||20181101||Shelf life||2020-10-30|
|Standard Adopted||In-house Standard|
|Appearance||White to off white powder||Conforms|
|Identification||IR, HPLC – Should comply||Conforms|
|LS-MS||Confirms to MW||PASS|
|Issued by:Xiaokang Ma||Checked by:Feng Yuan||Analyst:Peng He|
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