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|Product Name:||Cetirizine Hydrochloride||CAS:||83881-52-1|
Cetirizine is a potent H1 receptor antagonist that enters the body orally and rapidly binds to the histamine H1 receptor on the target cell membrane, blocking histamine from activating target cells. Cetirizine has no significant anticholinergic and anti-serotonin effects. At normal doses, it is not easy to penetrate the blood-brain barrier. This product can inhibit the histamine transmission in the initial stage of allergic reaction, reduce the migration activity of inflammatory cells and the release of transmitters in the late stage of allergic reaction, so it is also effective for allergic reactions in the late stage. This product is a highly selective H1 receptor antagonist, and has not been found to have adverse effects on cardiac electrical activity.
Cetirizine Hydrochloride is a second-generation H1 antihistamine that is a long-acting, selective oral potent antiallergic drug. H1 receptor antagonists have good anti-allergic reactions and are commonly used in allergic rhinitis, allergic skin itching, conjunctivitis and the like. Compared with its similar drugs such as diphenhydramine, promethazine and chlorpheniramine, cetirizine hydrochloride has a polar polarity and rarely crosses the blood-brain barrier, thus greatly reducing the central sedative effect and selective action. At the H1 receptor, there is little effect on the muscarinic choline receptor and the 5-HT receptor, so there are few side effects associated with anticholinergic activity. Judging from the use of this product at home and abroad, this product has strong anti-allergic activity. To reduce the area of the wheal caused by histamine, 10mg of this product is equivalent to three tablets of terfenadine 60mg. This product inhibits histamine-mediated allergic "early" and further reduces inflammatory cell migration and media release associated with "late" allergy. Patients with pollen allergy caused 10 or 15 mg orally twice a day, which can effectively reduce asthma, dyspnea and cough symptoms, and is more effective than terfenadine 60 mg twice a day. This product is faster than astemizole (domestic trade name: Sismin), is basically not metabolized, and is well tolerated.
Because cetirizine hydrochloride has good anti-allergic effect and has little side effects and can be tolerated, it has good clinical application prospects. However, its imported products are expensive and cannot be generally accepted by the majority of patients. Therefore, if we can reduce the cost through domestic production, it will bring considerable economic and social benefits.
With the development of modern industry, air pollution is becoming more and more serious, and harmful substances such as various harmful gases, dust, sensitized microorganisms and allergens are directly inhaled into the lungs, causing the incidence of respiratory diseases (especially allergic rhinitis and asthma) and Mortality is increasing. Statistics show that up to 25% of the world's population suffer from different types of allergic diseases.
This product is suitable for respiratory, skin and eye allergic diseases, including perennial allergic diseases such as allergic skin diseases, hives, allergic rhinitis, itchy eyes, conjunctivitis and asthma. This product is also used to treat various types of dermatological allergic diseases. Such as for chronic, artificial, cold, delayed stress, solar measles and atopic dermatitis. This product is also an effective drug for rapid whealing and rapid-onset nucleus and itching caused by mosquito bites.
Adult 10mg once a day. Elderly patients with renal dysfunction should reduce the dose of the drug, children aged 6-12 years 10mg / day or 5mg 2 times / day, children 2-6 years 5mg 1 time / day.
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