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99% Anti Estrogen Letrozole Femara Powder for Reducing Steroids Side-Effects
CAS No: 112809-51-5
Appearance: white powder.
1: Letrozole is an anti-estrogen of the Aromatase Inhibitor (AI) family and is one of the most potent and
powerfully effective of all AI’s.Letrozole was first developed in an effort to combat breast cancer in post-
menopausal women.While intended for breast cancer treatment, like many AI’s, it has found a welcomed
home among anabolic steroid users. Letrozole is one of the most commonly used anti-estrogens among
steroid users during steroid use to combat possible estrogenic related side effects. It is so effective as an
anti-estrogen in this regard many anabolic steroids have effectively reversed gynecomastia symptoms
2: Letrozole as an anti-estrogen is extremely beneficial to breast cancer patients. Many forms of breast
cancer actively feed off the estrogen hormone. By inhibiting the production of estrogen, which in turn
lowers the amount of circulating estrogen in the body, this has the ability to starve the cancer.
3: For the anabolic steroid user, the same anti-estrogenic effect provided by Letrozole is tremendously
beneficial. Many anabolic steroids have the ability to increase estrogen levels due to testosterone’s
interaction with the aromatase enzyme. As estrogen levels rise, this can lead to gynecomastia and excess water retention. If water retention becomes severe, this can in turn promote high blood pressure. While many anabolic steroids have the ability to aromatize and promote an increase in estrogen, not all anabolic steroids carry this ability. However, many common steroids carry this ability including Methandrostenolone (Dianabol) as well as all forms of testosterone. The Nandrolone (Deca Durabolin, Durabolin, NPP, etc.) and Boldenone (Equipoise) hormone also carry the ability to aromatize to a degree. Nandrolone will aromatize at approximately 20% the rate of testosterone and Boldenone at approximately 50%. While both aromatize significantly less than testosterone, it is enough to promote estrogenic related side effects. The probability is increased with Nandrolone as it carries a strong progestin nature. Progesterone has the ability to stimulate the estrogenic mechanism and can lead to gynecomastia. AI’s like Letrozole can be useful when using all the aforementioned steroids.
4: By including Letrozole in a cycle that contains aromatizing anabolic steroids, this can prevent the
estrogenic related side effects. This will protect the individual from gynecomastia and water retention.
Further, while many steroids can promote high blood pressure despite aromatization, an AI will improve
the individual’s odds when water retention is the culprit. Heavy excess water retention is normally the
number one cause of high blood pressure among steroid users.
5: With its ability to promote natural testosterone production, Letrozole is often an appealing choice for
Post Cycle Therapy (PCT) plans. This can also make it appealing for low testosterone treatment, but it’s
often not enough. However, for PCT purposes, while it can be effective it’s generally not recommended.
The primary purpose of PCT is stimulating natural testosterone production, which Letrozole can do very
well. However, part of the purpose of PCT is also normalization, which will be difficult with severely
suppressed estrogen levels. Estrogen is an important hormone as it promotes a stronger immune system
and healthier cholesterol levels. For the anabolic steroid user, his best bet for PCT is sticking with SERM’s
for his natural testosterone production needs.
6: Undeniably, AI’s like Letrozole are the most effect means at combating estrogenic related side effects.
However, they can also have a negative impact on cholesterol.
The recipe of Letrozole:
Powder: per 1 gram of Letrozole
Produces: Highest concentration made - 5 mg/ml
1 gram of Letrozole powder
1 beaker suitable for holding the volume of liquids
19.9 ml of PEG 300
179.1 ml of 190 Proof Grain Alcohol
use the following procedure:
place a sufficient amount of water in a pan and place on the stove
remove from heat when the water reaches boiling temperature
place the powder and the PEG in the beaker
immerse the beaker in the pan of water so that the water is level with the top of the contents of the beaker gently swirl or stir the contents of the beaker until the solution is clear (reheat the water if necessary)
remove the beaker from the water
allow the PEG to cool down
slowly add the 190 Proof Alcohol to the mixture
gently stir until fully mixed
|Appearance||White or off-white crystaline powder||White
|Solubility||Soluble in Chloroform;
Soluble in ethanol when heated
|ldentification||(1)Maximum absorption in wavelength
of 240 nm Minimum absorption in
wavelength of 215 nm
|(2)Infrared spectrum should be in
accordance the dominant peak of
|In accordance with the dominant
peak of contrast
|Melting points||182 degrees Celcius-184 degrees Celcius||182 degrees Celcius|
|Loss on drying||≤1.0%||0.8%|
(On anhydrous basis)
|Conclusion||The specification conforms with USP/BP|
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