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White Powder Fareston Anti Estrogen Steroids Toremifene Citrate for Treatment 89778-27-8

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White Powder Fareston Anti Estrogen Steroids Toremifene Citrate for Treatment 89778-27-8

China White Powder Fareston Anti Estrogen Steroids Toremifene Citrate for Treatment 89778-27-8 supplier
White Powder Fareston Anti Estrogen Steroids Toremifene Citrate for Treatment 89778-27-8 supplier White Powder Fareston Anti Estrogen Steroids Toremifene Citrate for Treatment 89778-27-8 supplier

Large Image :  White Powder Fareston Anti Estrogen Steroids Toremifene Citrate for Treatment 89778-27-8

Product Details:

Place of Origin: China
Brand Name: Yuancheng
Certification: ISO9001
Model Number: 89778-27-8

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Price: Negotiate
Packaging Details: Discreet packaging
Delivery Time: 4-7 working days
Payment Terms: Western Union, MoneyGram,bitcoin
Supply Ability: 5000KG/Month
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Detailed Product Description
Product Name: Toremifene Citrate CAS No: 89778-27-8
Assay: 99% Min Molecular Formula: C26H29NO.C6H8O7
Molecular Weight: 598.09 Appearance: White Crystalloid Powder

White Powder Fareston Anti Estrogen Toremifene Citrate for Treatment 89778-27-8

 

CAS 89778-27-8 Toremifene Citrate

Product Name:Toremifene Citrate
Synonyms:Fareston
CAS Registry Number:89778-27-8
Assay: 99%
Molecular Formula: C26H28ClNO.C6H8O7
Molecular Weight: 598.09
Melting Point: 158-164 ºC
Boiling Point: 535.1 ºC at 760 mmHg
Density: 1.045g/cm3
Refractive index: 1,416-1,418
Grade:Pharmaceutical Grade
Appearance: White or almost white powder


 

White Powder Fareston Anti Estrogen Steroids Toremifene Citrate for Treatment 89778-27-8
 

Pharmacological effects

Toremifene citrate binds to the estrogen receptor and produces estrogen-like or anti-estrogenic effects, or both, depending on the length of treatment, animal species, sex, and target organ. In general, the non-steroidal stilbene derivatives in humans and rats, mainly for anti-estrogen effect in mice showed estrogen-like effect. The use of toremifene in postmenopausal women with breast cancer resulted in a moderate decrease in serum total cholesterol and low-density lipoprotein (LDL).Toremifene citrate competes with estrogen to bind estrogen receptors in the cytoplasm of breast cancer cells, preventing estrogen-induced DNA synthesis and proliferation in cancer cells. Some experimental tumors using high-dose toremifene citrate showed that toremifene citrate had a non-estrogen-dependent antitumor effect. The anti-breast cancer effect of toremifene citrate is mainly anti-estrogenic, and there may be other anti-cancer mechanisms (changes in tumor gene expression, secretion of growth factors, induction of apoptosis and cell cycle dynamics).


Toremifene Citrate Effect

Toremifene citrate is an oral selective estrogen receptor modulator (SERM) which helps oppose the actions of estrogen in the body. Licensed in the United States under the brand name Fareston, toremifene citrate is FDA-approved for use in advanced (metastatic) breast cancer. It is also being evaluated for prevention of prostate cancer under the brand name Acapodene.

It has already been covered that Toremifene is a SERM, and serves to block Estrogen at various receptor sites in certain tissues within the body (breast tissue in particular). As a layman explanation, Toremifene pretends to be a ‘fake’ Estrogen that occupies Estrogen receptors within breast tissue. With these receptors occupied by Toremifene, real Estrogen cannot perform their jobs there. Toremifene does not reduce total blood plasma levels of Estrogen. In addition to being antagonistic to Estrogen receptors in breast tissue, it is also antagonistic to Estrogen at the hypothalamus gland (this essentially ‘tricks’ the hypothalamus into thinking there is little or no circulating Estrogen levels in the body, causing it to increase its manufacture of Testosterone so that it can utilize aromatization to restore these levels.

Toremifene Citrate exerts its effects by antagonizing the estrogen receptor in some tissues, and agonizing it in others. In this way, certain estrogenic pathways are activated and others are blockaded. It seems to exert estrogenic effects on blood lipids, reducing LDL and total cholesterol, as well as estrogenic effects on bone, improving density. It would also appear to exert anti-estrogenic effects in breast tissue, displacing the traditional effects of estrogen, effectively helping prevent breast cancer in postmenopausal women.


Fareston Administration

In the fight against breast cancer, standard Fareston doses will normally be 60mg per day. The total duration of use is unpredictable and will be based on patient need. It’s not uncommon for treatment to last a year or two and then AI’s to be added if needed. Once the cancer is in remission, compounds like Fareston are commonly used to support the improved state.

For the anabolic steroid user combating gynecomastia, standard Fareston doses will fall in the 30-60mg per day range and will work very well for most men. If this is not enough protection, while you could try increasing the dose your best bet would be to move to AI use. You will find Fareston works very well in combating gynecomastia due to the use of any testosterone, Dianabol and Anadrol. You will also find it works well with Equipoise and Deca Durabolin. However, as Deca Durabolin is also a progestin, men who are very sensitive to that hormone may need an AI. The same can be said of the Trenbolone hormone. Trenbolone does not aromatize, but it is a progestin. Further, the use of an aromatizing steroid with a compound like Trenbolone can increase the risk of gynecomastia in some men. While many will not need gynecomastia protection due to progestins and will get by with SERM’s to combat aromatase, some sensitive men will need an AI. Regardless, if Fareston works for you it will cover the entire breadth of the cycle from start to finish.

 

 

White Powder Fareston Anti Estrogen Steroids Toremifene Citrate for Treatment 89778-27-8
 

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