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Bimatoprost is used for the treatment of open-angle glaucoma and ocular hypertension in adult patients, either alone or in combination with a beta blocker(typically timolol).
Studies have shown bimatoprost to be more effective than timolol in reduction of intraocular pressure (IOP) and as least as effective as the prostaglandin analogs latanoprost and travoprost in reducing IOP.
In patients using ophthalmic prostaglandins such as travoprost and latanoprost, it has been noted that there had been an increase in diameter, density and length of eyelashes. A study published in May 2010 found that bimatoprost in a gel suspension, when applied at the base of the upper eyelid eyelashes, significantly increased eyelash length. Allergan initiated clinical trials investigating the usage of bimatoprost as a cosmetic drug.In 2008, the FDA Dermatologic and Ophthalmic Drugs Advisory Committee voted to approve bimatoprost for the cosmetic use of darkening and lengthening eyelashes.The medical term for this is treatment of hypotrichosis; however, the FDA approval is for purely cosmetic purposes (see Prostaglandin F receptor#Clinical Significance).
|CAS No.||155206-00-1||Outer Packing||1g/foil bag|
|Production date||2016/11/6||Shelf life||2018/11/5|
|Standard adopted||Enterprise standard|
|Items of analysis||Specification||Results|
|Appearance||White to almost white powder||White powder|
|Identification||HPLC retention time of sample complies with that of known sample||Complies|
|Specific rotation||[a ]D20 : +33.0° 〜+37.00 (C=1.0,CH3CN)||+35.4°|
|15R-Bimatoprost:||NMT 0.30%||Not detected|
|Bimatoprost free acid:||NMT 0.10%||Not detected|
|5,6-trans-Bimatoprost:||NMT 0.50% Any||0.15%|
|other single impurity:||NMT 0.10%||0.03%|
|Total other impurities:||NMT 0.50%||0.06%|
|Ter-Butylmethyl ether:||NMT 5000ppm||lppm|
|Ethanol: NMT 5000ppm n-Hexane:||NMT||36ppm 3 ppm|
|290ppm Ethyl acetate:||NMT 5000ppm||Not detected|