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|Product Name:||Paracetamol||CAS No:||103-90-2|
|EINECS No:||203-157-5||Molecular Formula:||C8H9NO2|
|Molecular Weight:||151.16||Appearance:||White Crystalline Powder|
Pharmaceutical raw materials Paracetamol, White powder CAS No 103-90-2
Product Name: Paracetamol
CAS No.: 103-90-2
EINECS No.: 203-157-5
Molecular Formula: C8H9NO2
Molecular Weight: 151.16
Melting point: 168-172 ° C(lit. )
Appearance: White crystalline powder
Application: Antipyretic Analgesics
Usage:used as analgesic-antipyretic pharmaceutical material
Paracetamol, also known as acetaminophen or APAP, chemically named N-acetyl-p-aminophenol, is a widely used over-the-counter analgesic (pain reliever) and antipyretic (fever reducer). Acetaminophen is the name adopted for this pharmacologic agent in the U. S. (USAN) and Japan; Paracetamol is approved in a variety of international venues (INN, AAN, BAN, etc. ). Common trade names in English-speaking markets are Tylenol and Panadol.
Paracetamol is classified as a mild analgesic. It is commonly used for the relief of headaches and other minor aches and pains and is a major ingredient in numerous cold and flu remedies. In combination with opioid analgesics, paracetamol can also be used in the management of more severe pain such as post-surgical pain and providing palliative care in advanced cancer patients. Though paracetamol is used to treat inflammatory pain, it is not generally classified as an NSAID because it exhibits only weak anti-inflammatory activity.
Paracetamol is approved for reducing fever in people of all ages. The World Health Organization (WHO) recommends that paracetamol be used to treat fever in children only if their temperature is greater than 38.5 ° C (101.3 ° F). The efficacy of paracetamol by itself in children with fevers has been questioned and a meta-analysis showed that it is less effective than ibuprofen.
Paracetamol is used for the relief of pains associated with many parts of the body. It has analgesic properties comparable to those of aspirin, while its anti-inflammatory effects are weaker. It is better tolerated than aspirin in patients in whom excessive gastric acid secretion or prolongation of bleeding time may be a concern. Available without a prescription since 1959, it has since become a common household drug.
Paracetamol has relatively little anti-inflammatory activity, unlike other common analgesics such as the NSAIDs aspirin and ibuprofen, but ibuprofen and paracetamol have similar effects in the treatment of headache. Paracetamol can relieve pain in mild arthritis, but has no effect on the underlying inflammation, redness, and swelling of the joint.
|Characters||White crystalline powder||Conforms|
|Identification||IR,UR,TCL Complies with the test for identification of Paracetamol||Conforms|
|Solubility||Sparingly soluable in water,freely soluable in alcohol,very slightly soluable in methylene chloride.||Conforms|
|Loss on drying||≤0.5%||0.06%|
|Residue on ignition||≤0.1%||0.04%|
|Readily carbonizable substances||Conforms||Conforms|
|Limit of p-chloroacetanilide||≤0.001%||<0.001%|
|Organic volatile impurities||Conforms||Conforms|
|Particle size||90% no more than 200μm||Conforms|
|50% no less than 50μm||Conforms|
|Conclusion: It complies with the requirements of the USP34|