CAS 74811-65-7 Croscarmellose Sodium uses as a super-disintegrant in pharmaceutical formulations
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CAS 74811-65-7 Croscarmellose Sodium  uses as a super-disintegrant in pharmaceutical formulations
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Place of Origin: China
Brand Name: Yuan Cheng
Certification: ISO9001
Model Number: CAS 74811-65-7
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raw materials testing pharmaceutical

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raw material pharmaceutical

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Packaging Details: Discreet package
Delivery Time: 4-7 work days
Payment Terms: Bank transfer,,MoneyGram,Bitcoin
Supply Ability: 5000kg/m
Specifications
Chemical Name: Croscarmellose Sodium
Appearance: White Powder
Email: Kevin@chembj.com
Purity: 99%
Whatsapp: +86 15372415908
Grade: Pharmaceutical Grade
CAS: 74811-65-7
MF: 0
MW: 0
Product Description

CAS 74811-65-7 Croscarmellose Sodium uses as a super-disintegrant in pharmaceutical formulations

 

 

CAS 74811-65-7 Croscarmellose Sodium

Product Name:Croscarmellose Sodium
Alias:Crosslinked Carboxymethylcellulose Sodium,Sodiumcroscarmellose,Crosscarmelosesodium
CAS NO.:74811-65-7
Purity:99%
Appearance:White Powder
Grade:Pharmaceutical Grade

 

 

Croscarmellose sodium is an internally cross-linked sodium carboxymethylcellulose for use as a super-disintegrant in pharmaceutical formulations.

 

 

The cross-linking reduces water solubility while still allowing the material to swell (like a sponge) and absorb many times its weight in water. As a result, it provides superior drug dissolution and disintegration characteristics, thus improving formulas′ subsequent bioavailability by bringing the active ingredients into better contact with bodily fluids.

 

 

Croscarmellose sodium also resolves formulators′ concerns over long-term functional stability, reduced effectiveness at high tablet hardness levels, and similar problems associated with other products developed to enhance drug dissolution. Croscarmellose sodium is a very commonly used pharmaceutical additive.Its purpose in most tablets - including dietary supplements - is to assist the tablet in disintegrating in the gastrointestinal tract promptly. If a tablet disintegrating agent is not included, the tablet could disintegrate too slowly, in the wrong part of the intestine or not at all, thereby reducing the efficacy and bioavailability of the active ingredients.

 

 

Croscarmellose is made by first soaking crude cellulose in sodium hydroxide, and then reacting the cellulose with sodium monochloroacetate to form sodium carboxymethylcellulose. Excess sodium monochloroacetate slowly hydrolyzes to glycolic acid and the glycolic acid catalyzes the cross-linkage to form croscarmellose sodium.Chemically, croscarmellose sodium is the sodium salt of a cross-linked, partly O-(carboxymethylated) cellulose.

 

CAS 74811-65-7 Croscarmellose Sodium  uses as a super-disintegrant in pharmaceutical formulations 0

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