Description
Raloxifene, a member of the class of selective estrogen receptor modulators (SERM), reproduces the beneficial effects of estrogens on the skeletal systems, without the negative effects estrogens on breast and endometrium.
This is a review article summarizing its mechanism, effects on bone and its applicability in traumatology clinical practice. In postmenopausal osteoporosis, this drug has been proven to decrease accelerated bone turnover, increase bone mineral density (BMD), and to structurally recover bone, decreasing the risk of vertebral fractures and the risk of non-vertebral fractures in patients with previous, severe vertebral fractures.
Moreover, raloxifene appears to lower the risk of invasive breast cancer. Raloxifene would be efficacious in the prevention and treatment of postmenopausal osteoporosis.
We can therefore conclude that raloxifene would be efficacious in the prevention and treatment of postmenopausal osteoporosis, while reducing the risk of breast cancer when used at the indicated dose of 60 mg/day and with a low incidence of side effects.
Advantage
Because of Raloxifene’s greater differences in its selectivity of Estrogen agonism and antagonism in different tissues in the body, there is ongoing investigation of its application in other diseases, including prostate cancer, acromegaly, uterine cancer, cardiovascular disease, and breast cancer.
Bodybuilders and anabolic steroid users are attracted to the use of Raloxifene due to its nature as an anti-estrogen in the fight against Estrogen-related side effects that are usually caused by the use of aromatizable androgens that result in high blood plasma levels of Estrogen in the body. A common estrogenic side effect as a result of this is the development of gynecomastia. In the realm of gynecomastia in particular, Raloxifene has actually demonstrated more promising effectiveness than Nolvadex (Tamoxifen).
As is common with all SERMs and anti-estrogens, Raloxifene has also demonstrated considerable benefit in stimulating endogenous natural Testosterone production in males, as studies have demonstrated an increase of serum Testosterone levels by 20% from 120mg of Raloxifene per day
Dosage
It is important to point out that this is a powerful anabolic androgenic steroid, and there is no real beginning step for using this product. It is best used by bodybuilders who are already experienced with steroid use. The average Trenbolone Acetate dose varies based on your cycle and stack. During an off-season bulking cycle, most bodybuilders find that 50mg every other day is comfortable and effective.
Some men tolerate up to 100mg every other day with no issues, and they find that this does offers the best results for them. During a cutting cycle, people tend to push the envelope a little more with Tren and utilize doses even higher than 100mg every other day, but not everyone can tolerate these as the risk of side effects increases. No one should ever use more than 200mg every other day, even if they seem to tolerate it well.
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