CAS 5630-53-5 Tibolone
Product name: Tibolone
Synonyms: Livial,Liviella
CAS No: 5630-53-5
EINECS:227-069-1
Molecular Formula: C26H34O4
Molecular Weight:312.45
Assay: 97.0%~103.0%
Appearance: White or off-white crystalline powder
Grade: Pharmaceutical Grade
Description
Tibolone (Livial/Liviella) is used mainly for treatment of endometriosis, as well as hormone replacement therapy in post-menopausal women. Tibolone is a synthetic steroid hormone drug, which is fairly non-selective in its binding profile, acting as an agonist mainly at estrogen receptors, with a preference for ER alpha. Tibolone has similar or greater efficacy compared to older hormone replacement drugs, but shares a similar side effect profile. It has also been investigated as a possible treatment for female sexual dysfunction.
Tibolone is a synthetic steroid hormone drug, which is fairly non-selective in its binding profile, acting as an agonist mainly at estrogen receptors, with a preference for ER alpha. It is used mainly for treatment of endometriosis,as well as hormone replacement therapy in post-menopausal women. Tibolone has similar or greater efficacy compared to older hormone replacement drugs, but shares a similar side effect profile.It has also been investigated as a possible treatment for female sexual dysfunction.
Applications
Tibolone is an estrogen-like compound used for the treatment of the symptoms associated with menopausal transition (i.e., climacteric symptoms) and also for the treatment of osteoporosis.Three major metabolites of tibolone are responsible for its tissue selective mechanism of action. Conversion into 3α- and 3β-hydroxy-tibolone results in estrogenic effects in brain, vagina, and bone. The isomer has progestrogenic and androgenic effects and does not cause estrogenic stimulation in the endometrium.A two-year longitudinal study indicates that low doses (1.25-2.5 mg) of tibolone effectively relieve climacteric symptoms and prevent loss of bone mass in early postmenopausal women.
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The COA of Tibolone:
| Synonym | Livial |
| CAS Number | 5630-53-5 |
| Molecular formula | C21H28O2 |
| Molecular weight | 312.4458 |
| Assays | 99% |
| Appearance |
Yellow or light yellow crystalline powder |
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