Follistatin 344 Raw Supplement Powders Human Growth Peptide Follistatin 344 FST For Bodybuilding
Synonyms: FST, FS, Activin-binding protein.
Appearance: Sterile Filtered White Lyophilized (Freeze-Dried)
Purity (by HPLC): 85%
Follistatin 344 Description:
Follistatin is fascinating protein that can increase muscle mass beyond natural potential by suppressing
myostatin. Scientists first identified follistatin while examining porcine (re: pig) follicular fluid in the ovaries.
Follistatin is naturally found in the skeletal muscle of almost all mammals with advanced or developed
characteristics, such as humans, rodents, and cows. Follistatin is high in the
non-essential amino acid cystine but unlike most proteins discussed in the fitness world, follistatin has
carbohydrates attached to it.
Follistatin, specifically Follistatin 344 (FS344), quickly gained popularity in the bodybuilding community as
a potential supplement to rapidly increase lean tissue mass. Another protein, follistatin-related gene
(FLRG) acts on similar pathways as FS344 regarding its muscle building properties. Increased lean tissue mass could give a bodybuilder an advantage in a competitive setting and be the differentiating factor between first and second place.
Follistatin 344 Application:
Follistatin (FST) is a secreted glycoprotein that was first identified as a follicle stimulating hormone
inhibiting substance in ovarian follicular fluid (1, 2). Human Follistatin cDNA encodes a 344 amino acid
(aa) protein with a 29 aa signal sequence, an Nterminal atypical TGF binding domain, three Follistatin
domains that contain EGFlike and kazallike motifs, and a highly acidic Cterminal tail. Follistatin is a
secreted protein that binds to ligands of the TGF-Beta family and regulates their activity by inhibiting their
access to signaling receptors. It was originally discovered as activin antagonists whose activity
suppresses expression and secretion of the pituitary hormone FSH (follicle stimulating hormone). In
addition to being a natural antagonist, follistatin can inhibit the activity of other TGF-Beta ligands including
BMP-2, -4, -6, -7, Myostatin, GDF-11, and TGF-Beta1. Follistatin is expressed in the pituitary, ovaries,
decidual cells of the endometrium, and in some other tissues. Recombinant human Follistatin is a 37.8
kDa protein containing 344 amino acids .
Follistatin works by binding to and inhibiting transforming growth factor- (TGF-) peptides such as
myostatin which is responsible for regulating and limiting muscle growth. It's also worth pointing out that
myostatin may have a regulatory role in skeletal muscle fibrosis; too much myostatin can impair tissue
function and cause chronic disease in vital organs, tissues, and bone marrow.
In additional to suppressing the degenerative properties of myostatin, follistatin also suppresses the
pituitary gland synthesis and secretion of follicle-stimulating hormone (FSH).  High FSH levels in men
may indicate that testicles are not functioning correctly; this condition limits muscle growth, recovery, and
normal hormonal function.However, FSH levels that are too low can also negatively impact health and
Follistatin 344 COA:
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