Pharmaceutical Grade A Popular Lubricant CAS 557-04-0 Magnesium Stearate Acts As A Glidant And Anti-Adherent
CAS 557-04-0 Magnesium Stearate
Product Name: Magnesium Stearate
CAS No.: 557-04-0
EINECS NO.: 209-150-3
Molecular Formula: C36H70MgO4,2(C18H35O2).Mg
Molecular Weight: 591.24
Melting point: 200 °C(lit.)
Appearance: White fine powder
Application: Stabilizing agent,lubricant
Magnesium stearate is a soap,consisting of salt containing two equivalents of stearate (the anion of stearic acid) and one magnesium cation (Mg2+). Magnesium stearate is a white, water-insoluble powder. Its applications exploit its softness, insolubility in many solvents, and low toxicity. It is used as a release agent and as a component or lubricant in the production of pharmaceuticals and cosmetics.
Magnesium Stearate is a popular lubricant because it also acts as a glidant and anti-adherent.Magnesium stearate is often used as an anti-adherent in the manufacture of medical tablets, capsules and powders.In this regard, the substance is also useful, because it has lubricating properties, preventing ingredients from sticking to manufacturing equipment during the compression of chemical powders into solid tablets; magnesium stearate is the most commonly used lubricant for tablets.Magnesium stearate can also be used efficiently in dry coating processes.
Magnesium stearate is used in the pharmaceutical drugs in order to bind tablets and make them smooth as well as shinier. Magnesium stearate has been graded to be a safe chemical compound, with no side effects known. Several foods use magnesium stearate as an additive or preservative.
Magnesium stearate (also known as octadecanoic acid) is a white magnesium salt that is solid at room temperature. It has the chemical formula C36H70MgO4. It is a salt containing two equivalents of stearate (the anion of stearic acid) and one magnesium cation (Mg2+). Stearic acid is a saturated 18 carbon chain fatty acid that is frequently found in meats as well as plant foods. The highest-quality vegetable based magnesium stearate we use in some of our formulations contains 92%-97% stearate with trace amounts of palmitate, a saturated 16-carbon chain fatty acid frequently found in foods. Due to its high stability it is unlikely that the body absorbs any of the magnesium stearate in a supplement formulation. Stearic acid itself, In supplement dosage forms, is used as an emulsifying agent, solubilizing agent, tablet and capsule lubricant.
Magnesium stearate melts at about 88°C, is not soluble in water, and is generally considered safe for human consumption (GRAS). Because it is widely regarded as harmless, it is often used as a filling agent in the manufacture of nutritional and pharmaceutical formulations. Magnesium Stearate serves as an efficient lubricant for mold release purposes during tabletting processes. Its hydrophobic (i.e., water-repelling) properties prevent finished products from absorbing water and improve flowability during capsule filling.
Magnesium stearate is typically used in a concentration range of 0.25%-2%. Higher values can result in decreased absorption of the product. We consequently limit magnesium stearate concentrations in our formulations to 1% or less. Whenever possible, we encourage our manufacturers instead to utilize silica and magnesium trisilicate at slightly higher levels in order to obtain the necessary lubricating/glidant effects. In most capsule formulations this works well. However, in tablet manufacture it is generally necessary to use magnesium stearate at the 1% concentration in order to enable tablet release from molds. In a few cases where an encapsulated product is greatly hydroscopic (i.e., water-absorbing) (such as l-carnosine and acetyl-l-carnitine), it is necessary to utilize up to 1% magnesium stearate in order to block excess moisture uptake leading to poor or uneven capsule filling.
|Melting point||200 °C(lit.)|
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