99% white Raw Local Anesthesia Agents powder Tetracaine HCL CAS136-47-0
Alias: Tetracaine; Tetracaine HCl
CAS: 136-47-0
EINECS: 205-248-5
M.F.: C15H25ClN2O2
M.W.: 300.82
Appearance:White crystalline powder
Descroptions and Applications:
Tetracaine HCl is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.
Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.
In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.
The COA of Tetracaine:
| Product name | Tetracaine HCl | |
| Appearance | White crystalline powder | |
| Assay | 98~101.0% | 100.4% |
| Identification | A.By UV, To match with working standard | Complies |
| B:Dissolve 100 mg in 10 mL of water, and add 1 mL of potassium thiocyanate Solution (1 in 4):A crystalline precipitate is formed.Recrystallize the precipitate From water, and dry at 80 for 2 hours:It melts between 130 and 132 . | Complies | |
| C.A solution of 100 mg in 5 mL of water meets the requirements of the Tests for Chloride | Complies | |
| PH Chromatographic purity Clarity | 4.5~6.5 | 5.9 |
| Conform to standard | Complies | |
| Solution should be clear | Complies | |
| Related Substances | Not more than the reference solution (0.05%) | Complies |
| Heavy metals | ≤10ppm | <10ppm |
| Loss on drying | <0.5% | 0.21% |
| Resiue on ignition | ≤0.1% | 0.05% |
| Melting range | 145~150°C | 146~149°C |
Other Local Anesthesia:
| Products’ name | |
benzocaine | 94-09-7 |
Benzocaine HCL | 23239-88-5 |
lidocaine | 137-58-6 |
| Lidocaine HCL | 73-78-9 |
| Procaine | 59-46-1 |
| Procaine hcl | |
Tetracaine | 94-24-6 |
| Tetracaine hcl | |
| Pramoxine hcl | |
Dibucaine hcl | 61-12-1 |
Prilocaine | 721-50-6 |
Prilocaine hcl | 1786-81-8 |
| Proparacaine hcl | 5875-06-9 |
| Articaine hcl | |
Levobupivacaine hcl | 27262-48-2 |
Ropivacaine hcl | 132112-35-7 |
Bupivacaine hcl | 14252-80-3 |
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