99% Raw Pharmaceutical DXM Powder Dextromethorphan Hydrobromide CAS125-69-9
Product Name: Dextromethorphan Hydrobromide
Synonyms:Delsym;Sisaal;Dextro;ROMILAR;medicon;tusilan;Tussade;antussan;metrorat;Dormetan;;Romilar;Tussade;
CAS No.: 125-69-9
Einecs No:204-750-1
Molecular Formula: C18H26BrNO
Molecular Weight: 352.31
Purity: 99.0%
Appearance: white crystalline powder
Standard: Enterprise Standard
Packing: 25KG/Drum or as per your requirements
Application: medical use
Dextromethorphan Hydrobromide (DXM or DM) is a drug of the morphinan class with sedative,
dissociative, and stimulant properties (at higher doses). It is a cough suppressant in many over-the-
counter cold and cough medicines including generic labels and store brands, Dextromethorphan
Hydrobromide has also found numerous other uses in medicine, ranging from pain relief (as either the
primary analgesic, or an opioid potentiator) over psychological applications to the treatment of addiction. It is sold in syrup, tablet, spray, and lozenge forms. In its pure form, Dextromethorphan Hydrobromide
occurs as a white powder.
DXM is also used recreationally. When exceeding label-specified maximum dosages, dextromethorphan
acts as a dissociative anesthetic. Its mechanism of action is via multiple effects, including actions as a
nonselective serotonin reuptake inhibitor and a sigma-1 receptor agonist.DXM and its major metabolite,
dextrorphan, also act as an NMDA receptor antagonist at high doses, which produces effects similar to,
yet distinct from, the dissociative states created by other dissociative anesthetics such as ketamine and
phencyclidine. Further, the metabolite 3-methoxymorphinan of dextrorphan (thus a second-level
metabolite of DXM) produces local anesthetic effects in rats with potency above dextrorphan, but below
that of DXM.
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The COA of Dextromethorphan Hydrobromide:
| Product name |
Dextromethorphan Hydrobromide |
||
| CAS No. |
6700-34-1 |
Outer Packing |
25KG /drum |
| Production date |
2016.06.11 |
Shelf life |
2020.06.10 |
| Standard adopted |
USP38/EP8 |
||
| Items of analysis | Specification | Results | |
|
Apperance |
Practically white crystal or crystalline powder |
White crystalline powder |
|
|
FT-IR |
The sample spectrum correspond to that of the reference standard |
Conforms |
|
|
UV |
Not more than 3.0% difference of RS(on anhydrous basis) |
2.7% |
|
|
Bromide Test |
Yellow white precipitate forme |
Conforms |
|
|
Specific rotation A |
1.8w/v in water:Not more than 1.0%difference of RS |
0.4% |
|
|
Specific rotation B |
2.0%w/v in 0.1M HCL: +28℃to +30℃ at 589nm and 20℃(on anhydrous basis) |
+28.4℃ |
|
|
Clarity of solution |
5.0%w/v in alcohol:Clear and colorless |
Conforms |
|
|
PH
PH |
5.2-6.5(1 in 100 water solution) |
5.7 |
|
|
Acidity or Alkalinity |
Not more than 0.4ml of 0.01M HCLconsumed |
0.30ml |
|
|
Water(by KF Titration) |
4.0%—5.5% |
4.9% |
|
|
impurities A,B,C,D |
For each of impurities A,B,C,D not more than 0.5% |
Impurities A,B,C,D; Not detected. |
|
|
impurities A,B,C,D |
Among impurities A,B,C,D not more than one greater than 0.25% |
0 |
|
|
For each of unspecified impurities |
not more than0.10% |
﹤0.05% |
|
|
Total impurities |
not more than 1.0% |
﹤0.05% |
|
|
Residue on Ignition |
Not more than 0.1% |
0.08% |
|
|
N-Dimethylaniline |
Not more than 0.001% |
Conforms |
|
|
Phenolic compounds |
No blue-green color develops |
Conforms |
|
|
Assay A (by HPLC) |
98.0%~102.0%(on anhydrous basis) |
99.9% |
|
|
Assay B(by titration) |
99.0%~101.0%(on anhydrous basis) |
99.2% |
|
|
Methanol |
≤3000ppm |
N.D |
|
|
Toluene |
≤890ppm |
5.8ppm |
|
|
Acetone |
≤5000ppm |
Conforms |
|
|
Storage |
Preserve in tight containers；protected from light |
Conforms |
|
| Conclusion | Qualified | ||
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