Isotretinoin Pharmaceutical Raw Materials Isotretinoin ATRA For Ance Treatment

Isotretinoin Basic info:

Accutane,Isotretinoin
Synonyms: 13-cis-ra;13-cis-retinoicaci;13-ra;Isoretinoin;isotrex;neovitaminaacid;ro-4-3780
CAS: 4759-48-2
MF: C20H28O2
MW: 300.44
EINECS: 225-296-0
Chemical Properties Yellow-Orange Crystalline Powder
Usage: Used as a treatment for severe acne. Presently being studied in conjuction with the treatment of photoaged skin.
General Description: Yellow-orange to orange crystalline powder; orange-brown chunky solid.
Air & Water Reactions Insoluble in water.

Isotretinoin Specification:

Items Specification Results
Description Orange-red crystal complies
Identification A The IR absorption spectrum should correspond complies
B Should exhibits maximum absorption at 354nm complies
Assay 98.0%-102.0% 100.2%
Loss on drying ≤0.5% 0.07%
Tretinoin ≤1.0% 0.1%
Residue on ignition ≤0.1% 0.02%
Heavy metals <0.002% <0.002%
Conclusion The product complies with USP34

Isotretinoin (Accutane) is primarily used to treat bad cases of cystic acne, and to help the skin more rapidly renew itself. In addition, it is used in rare cases for certain skin cancers and skin diseases. It is a type of retinoid, which is naturally found in the body in small amounts.

How it Works ?

Accutane works as an isomer of Vitamin A, which reduces the amount of oil released by the oil glands in the skin; this will make it difficult for acne to form and reduce it significantly. Nearly all patients achieve clearing of acne during a course, with 90% reporting‘excellent’ results with higher dosages.

Bodybuilding Use

Bodybuilders who use anabolic steroids have utilized accutane to counteract the negative effects of steroids on their skin; especially, the acne related side effects.
Since chances of acne are increased with anabolic steroid use, and bodybuilding requires looking good (especially physique competitors), many athletes who have failed to conquer their acne with natural remedies will turn to accutane.
It is the androgenic increases associated with steroids that will trigger increased acne. This is especially true for those genetically prone to the condition. Also, the hormonal changes can trigger acne as well, such as increased testosterone levels.

Accutane Dosage

Among bodybuilders, the dosage should be conservative. Once a day dose of 10-20mgs for 6-8 weeks maximum should work fine. Among the general public fighting acne, a dosage of 50-150mg per day may be prescribed by their physician. It is a good idea to take the drug with a large meal. In addition, it may be necessary to use multiple courses of treatment.

Isotretinoin Application

1.It is also somewhat effective for hidradenitis suppurativa and some cases of severe acne rosacea. It can also be used to help treat harlequin ichthyosis, lamellar ichthyosis and is used in xeroderma pigmentosum cases to relieve keratoses. Isotretinoin has been used to treat the extremely rare condition fibrodysplasia ossificans progressiva. It is also used for treatment of neuroblastoma, a form of nerve cancer.

2.Isotretinoin therapy has furthermore proven effective against genital warts in experimental use, but is rarely used due to potentially severe side effects. In a small-scale study, low dose oral isotretinoin showed considerable efficacy;

3.Isotretinoin may represent an efficacious and safe alternative systemic form of therapy for RCA of the cervix. Not many studies have been conducted to further confirm its effectiveness. In most countries this therapy is currently unapproved and only used if other therapies failed.

4.Isotretinoin's main indication is for the treatment of severe cystic acne vulgaris. Many dermatologists also support its use for treatment of lesser degrees of acne that prove resistant to other treatments, or that produce physical or psychological scarring.

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