Domperidone Quick Details:
|MW: 425.91||MSDS: Avaiable|
|Category: API||Min order: 10grams|
|Quality standard: USP||Place of Origin:China|
|Appearance||Domperidone is a selective inhibitor of the peripheral D2DR. The antidopaminergic effects of Domperidone have been correlated to antiemetic and gastroprokinetic action.|
|Applications||Pharmaceutical raw materials , A peripheral D2DR inhibitor|
Domperidone is a peripheral, specific blocker of dopamine receptors. It is administered orally, rectally, or intravenously. Domperidone is given in order to relieve nausea and vomiting; to increase the transit of food through the stomach (as a prokinetic agent through increase in gastrointestinal peristalsis); and to increase lactation (breast milk production) by release of prolactin. It is also used in the scientific study of the way dopamine (an important neurotransmitter) acts in the body.
There is some evidence that domperidone has antiemetic activity. Domperidone is used, together with metoclopramide, cyclizine, and 5HT3 receptor antagonists (such as granisetron) in the treatment of nausea and vomiting.
It can be used in patients with Parkinson's disease because, unlike metoclopramide, domperidone does not cross the blood–brain barrier.
Domperidone has also been found effective in the treatment of gastroparesis, a stomach motility condition, and for paediatric gastroesophageal reflux (infant vomiting).
In Canada, the drug is indicated "for the symptomatic management of upper gastrointestinal motility disorders associated with chronic and subacute gastritis and diabetic gastroparesis." The drug may also be used "to prevent gastrointestinal symptoms associated with the use of dopamine agonist antiparkinsonian agents".
|Appearance||White to off white powder||White powder|
Practically insoluble in water, soluble in dimethylformamide,
slightly soluble in ethanol(96%) and in methanol
|Identification||A. M.P. 244~248℃||244.5~245.5℃|
|B. IR should comply||Confirms|
|C. TLC should comply||Confirms|
|D. It gives the reaction of non-nitrogen substituted barbiturates.||Confirms|
|Clarity of solution||
The solution is clear and not more intensely colored than
reference solution Y6
|Related substance||Total impurities≤0.5%||≤0.29%|
|Loss on drying||≤0.5%||0.07%|
|Conclusion: This product conforms to the EP7.0 detection.|
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