99% Purity Pharmaceutical Raw Powder Azd-9291 for Lung Cancer
| AZD-9291 (Mesylate) | |
| Product Name: | AZD-9291 (Mesylate) |
| CAS: | 1421373-66-1 |
| MF: | C28H33N7O2.CH4O3S |
| MW: | 0 |
| Purity: | 99.56% |
| Appearance: | Light yellow powder |
| Grade: | Pharmaceutical Grade |
Official Title: A Phase III, Double-blind, Randomized, Placebo-controlled Multi-centre, Study to Assess the Efficacy and Safety of AZD9291 Versus Placebo, in Patients With Epidermal Growth Factor Receptor Mutation Positive Stage IB-IIIA Non-small Cell Lung Carcinoma, Following Complete Tumour Resection With or Without Adjuvant Chemotherapy (ADAURA).
Usage AZD 9291 is an irreversible inhibitor of epidermal growth factor receptor (EGFR) sensitizing and T790M resistance mutations (IC50s = 15-17 nM) while sparing the wild-type form of the receptor (IC50 = 480 nM). It binds the related IGF1R and hERG receptors with significantly reduced potency (IC50s = 2.9 and 16.2 μM, respectively). AZD 9291 has been shown to inhibit tumor growth in a xenograft mouse model at oral doses of 5-10 mg/kg and has been tested clinically in patients with advanced EGFR mutant non-small-cell lung cancer.[Cayman Chemical]
